10.1371/journal.pone.0163020.g003 Jörg Täubel Jörg Täubel Georg Ferber Georg Ferber Sara Fernandes Sara Fernandes Ulrike Lorch Ulrike Lorch Eva Santamaría Eva Santamaría Iñaki Izquierdo Iñaki Izquierdo Mean (±SD) plasma concentration. Public Library of Science 2016 PK-PD dose Cognitive Function Profile RT SAE RVP VAS rupatadine safety PD PK Japanese subjects Randomised Placebo-Controlled Trial Introduction Rupatadine 40 mg AUC SWM TEAE CNS 2016-09-15 17:30:01 Figure https://plos.figshare.com/articles/figure/Mean_SD_plasma_concentration_/3834237 <p>Profiles of rupatadine over time (A), UR-12790 (desloratadine) (B) and UR-12788 (3-hydroxydesloratadine) (C) following administration of single and multiple doses of rupatadine (10, 20 and 40 mg) on Days 1 and 5.</p>