Traceless OH-Directed Wacker Oxidation-Elimination, an Alternative to Wittig Olefination/Aldol Condensation: One-Pot Synthesis of <i>α</i>,<i>β</i>‑Unsaturated and Nonconjugated Ketones from Homoallyl Alcohols BethiVenkati FernandesRodney A. 2016 A new method for one-pot synthesis of <i>β-</i>substituted and <i>β</i>,<i>β</i><b>-</b>disubstituted <i>α</i>,<i>β</i>-unsaturated methyl ketones from homoallyl alcohols by sequential PdCl<sub>2</sub>/CrO<sub>3</sub>-promoted Wacker process followed by an acid-mediated dehydration reaction has been developed. Remarkably, internal homoallyl alcohols delivered regioselectively nonconjugated unsaturated carbonyl compounds under the same protocol. A new starting material-based synthesis of <i>α</i>,<i>β</i>-unsaturated and nonconjugated methyl ketones is demonstrated.