Traceless OH-Directed Wacker Oxidation-Elimination, an Alternative to Wittig Olefination/Aldol Condensation: One-Pot Synthesis of <i>α</i>,<i>β</i>‑Unsaturated and Nonconjugated Ketones from Homoallyl Alcohols Venkati Bethi Rodney A. Fernandes 10.1021/acs.joc.6b01899.s001 https://acs.figshare.com/articles/journal_contribution/Traceless_OH-Directed_Wacker_Oxidation-Elimination_an_Alternative_to_Wittig_Olefination_Aldol_Condensation_One-Pot_Synthesis_of_i_i_i_i_Unsaturated_and_Nonconjugated_Ketones_from_Homoallyl_Alcohols/3811392 A new method for one-pot synthesis of <i>β-</i>substituted and <i>β</i>,<i>β</i><b>-</b>disubstituted <i>α</i>,<i>β</i>-unsaturated methyl ketones from homoallyl alcohols by sequential PdCl<sub>2</sub>/CrO<sub>3</sub>-promoted Wacker process followed by an acid-mediated dehydration reaction has been developed. Remarkably, internal homoallyl alcohols delivered regioselectively nonconjugated unsaturated carbonyl compounds under the same protocol. A new starting material-based synthesis of <i>α</i>,<i>β</i>-unsaturated and nonconjugated methyl ketones is demonstrated. 2016-08-26 00:00:00 Olefination compound acid-mediated dehydration reaction sequential homoallyl alcohols Wittig Homoallyl β- method Synthesi Condensation Ketone PdCl Traceless OH-Directed Wacker Oxidation-Elimination one-pot Nonconjugated nonconjugated methyl ketones Remarkably carbonyl disubstituted CrO material-based One-Pot Alternative synthesis Unsaturated regioselectively