de Miranda É.J.F., Peixoto M.S., Bittencourt I.S., Santos P.A., Lotufo I.M., Benseñor Supplementary Material for: Thyroid Function and High-Sensitivity C-Reactive Protein in Cross-Sectional Results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): Effect of Adiposity and Insulin Resistance <i>Background:</i> Subclinical hypothyroidism (SCH) is associated with an increased cardiovascular risk, but little information is available about its association with high-sensitivity C-reactive protein (hs-CRP). <i>Objectives:</i> This study aims to analyze the association between SCH and hs-CRP using baseline data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). <i>Methods:</i> The study has a cross-sectional design. We included subjects with normal thyroid function (thyroid-stimulating hormone, TSH, 0.4-4.0 μIU/ml and normal free thyroxine, fT4, 10.3-24.45 pmol/l) and SCH (TSH >4.0 μIU/ml and normal fT4) who were evaluated for hs-CRP. We excluded individuals on medications that affect thyroid function and those who had prevalent cardiovascular disease. Multivariate linear regression evaluated hs-CRP and TSH as continuous variables, and logistic regression models assessed hs-CRP ≥19.05 nmol/l as the dependent variable and crescent quintiles of TSH as the independent variables adjusted for demographic and cardiovascular risk factors. <i>Results:</i> We included 12,284 subjects with a median age of 50 years (interquartile range = 45-57); 6,408 (52.2%) were female, 11,589 (94.3%) were euthyroid, and 695 (5.7%) had SCH. Bivariate analyses of participants stratified into quintiles of TSH revealed differences according to hs-CRP but not the Framingham risk score. The fifth quintile of TSH was not associated with elevated hs-CRP, odds ratio = 1.11 (95% confidence interval = 0.98-1.26), p = 0.102, in a fully adjusted logistic model, also consistent with the linear model (β = 0.024, p = 0.145). <i>Conclusions:</i> TSH is not associated with hs-CRP. Obesity and insulin resistance are very important confounders in the study of the association between SCH and hs-CRP. Cardiovascular risk factors;C-reactive protein;Insulin resistance;Obesity;Subclinical hypothyroidism;Systemic inflammation;Thyroid dysfunction 2016-09-02
    https://karger.figshare.com/articles/dataset/Supplementary_Material_for_Thyroid_Function_and_High-Sensitivity_C-Reactive_Protein_in_Cross-Sectional_Results_from_the_Brazilian_Longitudinal_Study_of_Adult_Health_ELSA-Brasil_Effect_of_Adiposity_and_Insulin_Resistance/3803172
10.6084/m9.figshare.3803172.v1