TY - DATA T1 - Working models of the regulatory networks of c-di-GMP signaling in S. typhimurium leading to suppression of invasion and IL-8 induction. PY - 2011/12/02 AU - Irfan Ahmad AU - Agaristi Lamprokostopoulou AU - Soazig Le Guyon AU - Elena Streck AU - Melanie Barthel AU - Verena Peters AU - Wolf-Dieter Hardt AU - Ute Römling UR - https://plos.figshare.com/articles/figure/_Working_models_of_the_regulatory_networks_of_c_di_GMP_signaling_in_S_typhimurium_leading_to_suppression_of_invasion_and_IL_8_induction_/378297 DO - 10.1371/journal.pone.0028351.g011 L4 - https://ndownloader.figshare.com/files/707947 KW - models KW - networks KW - c-di-gmp KW - signaling KW - suppression KW - il-8 N2 - (A) A model of the c-di-GMP signaling network for the suppression of the invasion phenotype by c-di-GMP signaling. Shown are di-guanylate cyclases and phosphodiesterases with the most pronounced effect on invasion. Activity of the di-guanylate cyclases STM1987 and STM4551 and the phosphodiesterases STM3611 and STM4262 create different c-di-GMP pools which subsequently affect target outputs. Upon elevated c-di-GMP, the invasion phenotype is negatively regulated by c-di-GMP signaling through the cellulose synthase BcsA and the biofilm regulator CsgD. CsgD inhibits secretion of TTSS-1 effector protein SipA. SipA secretion is affected by GGDEF and EAL domain proteins. Whether motility affects the invasion phenotype needs to be demonstrated. (B) Model of the c-di-GMP signaling network for the suppression of the IL-8 induction phenotype by c-di-GMP signaling. The c-di-GMP pool created by the di-guanylate cyclase STM1283 is degraded by the phosphodiesterases STM0468, STM1703, STM2503, STM3375 and STM4264 which are shown in the order of affection of the IL-8 induction phenotype. Upon elevation of c-di-GMP the resulting c-di-GMP pool is suggested to stimulate CsgD expression which subsequently represses IL-8 induction. ER -