%0 Journal Article %A Zhang, Gang %A Zhang, Na %A Xu, Li %A Wu, Hong-Tan %A Chen, Dan %A Lin, Qi-Huang %A Luo, Lian-Zhong %D 2016 %T A new piperidine alkaloid from the leaves of Microcos paniculata L. %U https://tandf.figshare.com/articles/journal_contribution/A_new_piperidine_alkaloid_from_the_leaves_of_i_Microcos_paniculata_i_L_/3753609 %R 10.6084/m9.figshare.3753609.v1 %2 https://ndownloader.figshare.com/files/5851104 %K Piperidine alkaloids %K Microcos paniculata %K cytotoxicity %X

A new piperidine alkaloid, microcosamine C (1), and one known compound, microcosamine A (2) were isolated from the leaves of Microcos paniculata. Structure elucidation was carried out using HR-ESI-MS, 1D and 2D NMR spectroscopic methods and by comparison with data reported in the literature. The absolute configuration at the C-3 hydroxy group of 1 was established by a Mosher esterification procedure. Both the isolates (12) were evaluated for cytotoxicity against four selected tumour cell lines and showed only weak activity against RAW 264.7 cell line.

%I Taylor & Francis