10.6084/m9.figshare.3749898.v1
Horst Romm
Horst
Romm
Elizabeth A. Ainsbury
Elizabeth A.
Ainsbury
Joan Francesc Barquinero
Joan
Francesc Barquinero
Leonardo Barrios
Leonardo
Barrios
Christina Beinke
Christina
Beinke
Alexandra Cucu
Alexandra
Cucu
Mercedes Moreno Domene
Mercedes Moreno
Domene
Silvia Filippi
Silvia
Filippi
Octávia Monteiro Gil
Octávia Monteiro
Gil
Eric Gregoire
Eric
Gregoire
Valeria Hadjidekova
Valeria
Hadjidekova
Vasia Hatzi
Vasia
Hatzi
Carita Lindholm
Carita
Lindholm
Radhia M´ kacher
Radhia M´
kacher
Alegria Montoro
Alegria
Montoro
Jayne Moquet
Jayne
Moquet
Mihaela Noditi
Mihaela
Noditi
Ursula Oestreicher
Ursula
Oestreicher
Fabrizio Palitti
Fabrizio
Palitti
Gabriel Pantelias
Gabriel
Pantelias
María Jesús Prieto
María Jesús
Prieto
Irina Popescu
Irina
Popescu
Kai Rothkamm
Kai
Rothkamm
Natividad Sebastià
Natividad
Sebastià
Sylwester Sommer
Sylwester
Sommer
Georgia Terzoudi
Georgia
Terzoudi
Antonella Testa
Antonella
Testa
Andrzej Wojcik
Andrzej
Wojcik
Web based scoring is useful for validation and harmonisation of scoring criteria within RENEB
Taylor & Francis Group
2016
Web based scoring
biological dosimetry
dicentric assay
radiation
biodosimetry network
2016-08-22 18:09:53
Dataset
https://tandf.figshare.com/articles/dataset/Web_based_scoring_is_useful_for_validation_and_harmonisation_of_scoring_criteria_within_RENEB/3749898
<p><b>Purpose:</b> To establish a training data set of digital images and to investigate the scoring criteria and dose assessment of the dicentric assay within the European network of biodosimetry (RENEB), a web based scoring inter-comparison was undertaken by 17 RENEB partners.</p> <p><b>Materials and methods:</b> Two sets of 50 high resolution images were uploaded onto the RENEB website. One set included metaphases after a moderate exposure (1.3 Gy) and the other set consisted of metaphases after a high dose exposure (3.5 Gy). The laboratories used their own calibration curves for estimating doses based on observed aberration frequencies.</p> <p><b>Results:</b> The dose estimations and 95% confidence limits were compared to the actual doses and the corresponding z-values were satisfactory for the majority; only the dose estimations from two laboratories were too low or too high. The coefficients of variation were 17.6% for the moderate and 11.2% for the high dose. Metaphases with controversial results could be identified for training purposes.</p> <p><b>Conclusions:</b> Overall, the web based scoring of the two galleries by the 17 laboratories produced very good results. Application of web based scoring for the dicentric assay may therefore be a relevant strategy for an operational biodosimetry assistance network.</p>