10.6084/m9.figshare.3749898.v1 Horst Romm Horst Romm Elizabeth A. Ainsbury Elizabeth A. Ainsbury Joan Francesc Barquinero Joan Francesc Barquinero Leonardo Barrios Leonardo Barrios Christina Beinke Christina Beinke Alexandra Cucu Alexandra Cucu Mercedes Moreno Domene Mercedes Moreno Domene Silvia Filippi Silvia Filippi Octávia Monteiro Gil Octávia Monteiro Gil Eric Gregoire Eric Gregoire Valeria Hadjidekova Valeria Hadjidekova Vasia Hatzi Vasia Hatzi Carita Lindholm Carita Lindholm Radhia M´ kacher Radhia M´ kacher Alegria Montoro Alegria Montoro Jayne Moquet Jayne Moquet Mihaela Noditi Mihaela Noditi Ursula Oestreicher Ursula Oestreicher Fabrizio Palitti Fabrizio Palitti Gabriel Pantelias Gabriel Pantelias María Jesús Prieto María Jesús Prieto Irina Popescu Irina Popescu Kai Rothkamm Kai Rothkamm Natividad Sebastià Natividad Sebastià Sylwester Sommer Sylwester Sommer Georgia Terzoudi Georgia Terzoudi Antonella Testa Antonella Testa Andrzej Wojcik Andrzej Wojcik Web based scoring is useful for validation and harmonisation of scoring criteria within RENEB Taylor & Francis Group 2016 Web based scoring biological dosimetry dicentric assay radiation biodosimetry network 2016-08-22 18:09:53 Dataset https://tandf.figshare.com/articles/dataset/Web_based_scoring_is_useful_for_validation_and_harmonisation_of_scoring_criteria_within_RENEB/3749898 <p><b>Purpose:</b> To establish a training data set of digital images and to investigate the scoring criteria and dose assessment of the dicentric assay within the European network of biodosimetry (RENEB), a web based scoring inter-comparison was undertaken by 17 RENEB partners.</p> <p><b>Materials and methods:</b> Two sets of 50 high resolution images were uploaded onto the RENEB website. One set included metaphases after a moderate exposure (1.3 Gy) and the other set consisted of metaphases after a high dose exposure (3.5 Gy). The laboratories used their own calibration curves for estimating doses based on observed aberration frequencies.</p> <p><b>Results:</b> The dose estimations and 95% confidence limits were compared to the actual doses and the corresponding z-values were satisfactory for the majority; only the dose estimations from two laboratories were too low or too high. The coefficients of variation were 17.6% for the moderate and 11.2% for the high dose. Metaphases with controversial results could be identified for training purposes.</p> <p><b>Conclusions:</b> Overall, the web based scoring of the two galleries by the 17 laboratories produced very good results. Application of web based scoring for the dicentric assay may therefore be a relevant strategy for an operational biodosimetry assistance network.</p>