10.1021/ol034958l.s001
Samir BouzBouz
Samir
BouzBouz
Janine Cossy
Janine
Cossy
Stereoselective Synthesis of the C1−C13
Fragment of (+)-Discodermolide Using
Asymmetric Allyltitanations
American Chemical Society
2003
Z configuration
metathesi
Stereoselective Synthesis
Discodermolide
Fragment
aldehyde
olefin
discodermolide
synthesis
fragment
Asymmetric Allyltitanations
stereogenic centers
crotyltitanation
enantioselective allyl
2003-07-25 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Stereoselective_Synthesis_of_the_C1_C13_Fragment_of_-Discodermolide_Using_Asymmetric_Allyltitanations/3747591
The synthesis of the C1−C13 fragment of (+)-discodermolide has been achieved. The configurations of the stereogenic centers have been
controlled by enantioselective allyl- and crotyltitanations of aldehydes, and the <i>Z</i> configuration of the olefin at C8−C9 was controlled by a
ring-closing metathesis.