10.1021/ol006145s.s001
Adam Golebiowski
Adam
Golebiowski
Sean R. Klopfenstein
Sean R.
Klopfenstein
Xia Shao
Xia
Shao
Jack J. Chen
Jack J.
Chen
Anny-Odile Colson
Anny-Odile
Colson
Arthur L. Grieb
Arthur L.
Grieb
Anne F. Russell
Anne F.
Russell
Solid-Supported Synthesis of a Peptide
β-Turn Mimetic
American Chemical Society
2000
bicyclic diketopiperazine
amine
resin ester
acid
Peptide
Ugi reaction
synthesis
peptide
aldehyde
bromo
isocyanide
Mimetic
Synthesi
2000-08-03 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Solid-Supported_Synthesis_of_a_Peptide_-Turn_Mimetic/3736686
The solid-supported synthesis of a bicyclic diketopiperazine, a potential peptide β-turn mimetic, is described. The Ugi reaction between the
resin ester of α-<i>N</i>-Boc-diaminopropionic acid (an amine input), α-bromo acid, aldehyde, and isocyanide is the key step in the proposed
protocol.