TY - DATA T1 - Solid Phase Syntheses of Polyamine Toxins HO-416b and PhTX-433. Use of an Efficient Polyamide Reduction Strategy That Facilitates Access to Branched Analogues PY - 2000/05/05 AU - Fan Wang AU - Sukhdev Manku AU - Dennis G. Hall UR - https://acs.figshare.com/articles/journal_contribution/Solid_Phase_Syntheses_of_Polyamine_Toxins_HO-416b_and_PhTX-433_Use_of_an_Efficient_Polyamide_Reduction_Strategy_That_Facilitates_Access_to_Branched_Analogues/3736068 DO - 10.1021/ol005817b.s001 L4 - https://ndownloader.figshare.com/files/5827836 KW - polyamine chains KW - Efficient Polyamide Reduction Strategy KW - Solid Phase Syntheses KW - synthesis KW - trityl derivatized resin KW - polyamide precursors KW - Facilitates Access KW - borane reduction protocol KW - Polyamine KW - PhTX isomer 3 KW - HO N2 - Polyamine toxins HO-416b (1) and PhTX-433 (2) isolated from the venom of insects are important lead compounds in neuropharmacology. Their total synthesis has been achieved on a trityl derivatized resin in good yield and purity using a mild borane reduction protocol to access the polyamine chains from polyamide precursors. The synthesis of PhTX isomer 3 demonstrates the potential of this strategy for the generation of branched analogues. ER -