New Trichothecenes Isolated from <i>Holarrhena </i><i>f</i><i>loribunda</i>
Ali Loukaci
Oliver Kayser
K.-U. Bindseil
Karsten Siems
J. Frevert
Pedro M. Abreu
10.1021/np990332l.s001
https://acs.figshare.com/articles/journal_contribution/New_Trichothecenes_Isolated_from_i_Holarrhena_i_i_f_i_i_loribunda_i_/3734946
Bioassay-guided fractionation of an extract of <i>Holarrhena floribunda</i> stem, has led to the isolation of the
new trichothecenes, 8-dihydrotrichothecinol A (<b>1</b>), loukacinol A (<b>2</b>), and loukacinol B (<b>3</b>), and the known
compounds, trichothecolone (<b>4</b>), trichothecin (<b>5</b>), trichothecinol A (<b>6</b>), rosenonolactone (<b>7</b>), 6β-hydroxyrosenonolactone (<b>8</b>), and rosololactone (<b>9</b>). The structures were determined by spectral and chemical
methods, and absolute configurations were established by a modified Horeau's method using HPLC.
Compounds <b>1</b> and <b>6</b> exhibited significant cytotoxicity against several human tumor cell lines, whereas
compound <b>8</b> showed moderate and weak antileishmanial activity toward extracellular and intracellular
<i>Leishmania donovani</i>, respectively.
1999-12-04 00:00:00
compound 8
rosololactone
fractionation
rosenonolactone
Compounds 1
antileishmanial activity
intracellular Leishmania donovani
New Trichothecenes
trichothecin
HPLC
cytotoxicity
tumor cell lines
trichothecolone
dihydrotrichothecinol
configuration
trichothecene
trichothecinol
hydroxyrosenonolactone
loukacinol B
isolation
extracellular
Horeau
Holarrhena floribunda
chemical methods