Synthesis, Structure, and Antiproliferative Activity of Ruthenium(II) Arene Complexes of Indenoisoquinoline Derivatives WambangNathalie Schifano-FauxNadège MartoriatiAlain HenryNatacha BaldeyrouBrigitte Bal-MahieuChristine BousquetTill PellegriniSylvain MeignanSamuel CailliauKatia GoossensJean-François BodartJean-François T. NdifonPeter PélinskiLydie 2016 Novel ruthenium complexes of indenoisoquinoline derivatives were synthesized and characterized. The structure of the complex <b>9</b> was determined by single-crystal X-ray crystallography. Ruthenium complexes displayed strong DNA interactions. The cytotoxic activity of the complexes was tested against five cancer cell lines (MDA-MB-231, MCF-7, HEK-293, HT-29, and DU-145).