10.1021/jo980453a.s001 Ahmad Yazbak Ahmad Yazbak Subhash C. Sinha Subhash C. Sinha Ehud Keinan Ehud Keinan Total Synthesis of Uvaricin American Chemical Society 1998 skeleton functionalized manner enantioselectively synthesis Williamson type etherification reaction dihydroxylation oxygen functions Sharples AD regio Uvaricin Total Synthesis uvaricin 1998-08-01 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Total_Synthesis_of_Uvaricin/3712068 The first total synthesis of naturally occurring (+)-uvaricin was achieved using three consecutive Sharpless asymmetric dihydroxylation (AD) reactions to place the necessary oxygen functions on a “naked” carbon skeleton in a regio- and enantioselectively controlled manner. The appropriate bis-THF ring system was constructed using a Williamson type etherification reaction on a functionalized bis-mesylate intermediate.