10.1021/jo034785d.s001 Lucia Raffaella Lampariello Lucia Raffaella Lampariello Daniela Piras Daniela Piras Manuela Rodriquez Manuela Rodriquez Maurizio Taddei Maurizio Taddei Solid-Phase Synthesis of Conformationally Constrained Peptidomimetics Based on a 3,6-Disubstituted-1,4-diazepan-2,5-dione Core American Chemical Society 2003 agent DMTMM Core platform hydroxamic dipeptide serine Synthesi heterocycle rigidify yield Disubstituted combinatorial chemistry hydroxylamine constraint microwave heating Mitsunobu cyclization Conformationally Constrained Peptidomimetics 2003-08-30 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Solid-Phase_Synthesis_of_Conformationally_Constrained_Peptidomimetics_Based_on_a_3_6-Disubstituted-1_4-diazepan-2_5-dione_Core/3700218 Starting from a Cl-trytyl linked hydroxylamine, a hydroxamic dipeptide having serine in the second position was prepared by using DMTMM as the coupling agent. Mitsunobu cyclization carried out under microwave heating gave very good yields of a 3,6-disubstituted-perhydro-diazepin-2,5-dione. This heterocycle can be used as a new platform for combinatorial chemistry or as a constraint to rigidify a small peptide.