Mimicry of Annonaceous Acetogenins:  Enantioselective Synthesis of a (4<i>R</i>)-Hydroxy Analogue Having Potent Antitumor Activity Sheng Jiang Zhong-Hai Liu Gang Sheng Bu-Bing Zeng Xiao-Guang Cheng Yu-Lin Wu Zhu-Jun Yao 10.1021/jo016396u.s001 https://acs.figshare.com/articles/journal_contribution/Mimicry_of_Annonaceous_Acetogenins_Enantioselective_Synthesis_of_a_4_i_R_i_-Hydroxy_Analogue_Having_Potent_Antitumor_Activity/3692961 The (4<i>R</i>)-hydroxylated analogues of annonaceous acetogenin mimicking compound <b>2</b> were designed and synthesized structurally on the basis of the naturally occurring annonaceous acetogenin bullatacin, which was discovered as a typical member of the novel family of polyketides with potent cytotoxicity, antitumoral, and other biological activities. The preliminary screenings show that the IC<sub>50</sub> values of <b>2</b> were 1.6 × 10<sup>-3</sup> and 8 × 10<sup>-2</sup> μg/mL against HT-29 and HCT-8, respectively. A remarkable enhancement effect was observed by the activity comparison of <b>1c</b> and its (4<i>R</i>)-hydroxylated analogue <b>2</b>. 2002-04-20 00:00:00 Annonaceou Enantioselective 1 c 1.6 HT compound 2 activity comparison analogue Mimicry hydroxylated enhancement effect basis polyketide novel family antitumoral member screenings show IC 50 values Synthesi HCT Acetogenin annonaceous acetogenin Hydroxy cytotoxicity Potent Antitumor Activity Analogue annonaceous acetogenin bullatacin