%0 Journal Article
%A Natale, Nicholas R.
%A Rogers, Mark E.
%A Staples, Richard
%A Triggle, David J.
%A Rutledge, Aleta
%D 1999
%T Lipophilic 4-Isoxazolyl-1,4-dihydropyridines:  Synthesis and Structure−Activity
Relationships
%U https://acs.figshare.com/articles/journal_contribution/Lipophilic_4-Isoxazolyl-1_4-dihydropyridines_Synthesis_and_Structure_Activity_Relationships/3683973
%R 10.1021/jm980439q.s001
%2 https://ndownloader.figshare.com/files/5774328
%K calcium channel
%K series
%K binding
%K SAR
%K lipophilic side chains
%K compound
%K model
%X A series of 4-isoxazolyl-1,4-dihydropyridines bearing lipophilic side chains at the C-5 position
of the isoxazole ring have been prepared. The calcium channel antagonistic activity of these
compounds has been evaluated. A hypothetical model for binding of these compounds in the
calcium channel is proposed, and the validity of this model is evaluated based on the SAR of
this series of calcium binding, especially for the two most active derivatives, 1a,g. The solid-state structure for the most active compound, 1a, has also been determined, and its important
features are reported.
%I ACS Publications