Biosynthesis of Hyperforin in <i>Hypericum </i><i>p</i><i>erforatum</i>
Petra Adam
Duilio Arigoni
Adelbert Bacher
Wolfgang Eisenreich
10.1021/jm0209782.s001
https://acs.figshare.com/articles/journal_contribution/Biosynthesis_of_Hyperforin_in_i_Hypericum_i_i_p_i_i_erforatum_i_/3681438
Cut sprouts of <i>Hypericum perforatum</i> were proffered solutions containing [1-<sup>13</sup>C]glucose or
[U-<sup>13</sup>C<sub>6</sub>]glucose. Hyperforin was isolated and analyzed by quantitative NMR spectroscopy. The
labeling patterns show that the biosynthesis of hyperforin involves five isoprenoid moieties,
which are derived entirely or predominantly (>98%) via the deoxyxylulose phosphate pathway.
The phloroglucinol moiety is generated via a polyketide type mechanism.
2002-09-17 00:00:00
13 C 6
Biosynthesi
deoxyxylulose phosphate pathway
hyperforin
polyketide type mechanism
Hypericum p erforatum
isoprenoid moieties
biosynthesi
NMR spectroscopy
glucose
phloroglucinol moiety
patterns show
solution
Hypericum perforatum
Hyperforin