Biosynthesis of Hyperforin in <i>Hypericum </i><i>p</i><i>erforatum</i> Petra Adam Duilio Arigoni Adelbert Bacher Wolfgang Eisenreich 10.1021/jm0209782.s001 https://acs.figshare.com/articles/journal_contribution/Biosynthesis_of_Hyperforin_in_i_Hypericum_i_i_p_i_i_erforatum_i_/3681438 Cut sprouts of <i>Hypericum perforatum</i> were proffered solutions containing [1-<sup>13</sup>C]glucose or [U-<sup>13</sup>C<sub>6</sub>]glucose. Hyperforin was isolated and analyzed by quantitative NMR spectroscopy. The labeling patterns show that the biosynthesis of hyperforin involves five isoprenoid moieties, which are derived entirely or predominantly (>98%) via the deoxyxylulose phosphate pathway. The phloroglucinol moiety is generated via a polyketide type mechanism. 2002-09-17 00:00:00 13 C 6 Biosynthesi deoxyxylulose phosphate pathway hyperforin polyketide type mechanism Hypericum p erforatum isoprenoid moieties biosynthesi NMR spectroscopy glucose phloroglucinol moiety patterns show solution Hypericum perforatum Hyperforin