Dai, Wei-Min Lai, Kwong Wah Wu, Anxin Hamaguchi, Wataru Lee, Mavis Yuk Ha Zhou, Ling Ishii, Atsushi Nishimoto, Sei-ichi DNA Cleavage Potency, Cytotoxicity, and Mechanism of Action of a Novel Class of Enediyne Prodrugs We have discovered a novel class of (<i>E</i>)-3-acyloxy-4-(arylmethylidene)cyclodeca-1,5-diynes which exhibit promising enediyne-like DNA cleavage and cytotoxic activities. LC-MS analysis of the incubation mixture (pH 8.5, 37 °C) confirmed formation of 10-membered ring enediyne presumably via an allylic cation and suggested that the 1,4-benzenoid diradical might be one of the active species for DNA damage and cytotoxicity. cytotoxic activities;Novel Class;Enediyne Prodrugs;allylic cation;DNA Cleavage Potency;DNA damage;novel class;incubation mixture 2002-01-17
    https://acs.figshare.com/articles/journal_contribution/DNA_Cleavage_Potency_Cytotoxicity_and_Mechanism_of_Action_of_a_Novel_Class_of_Enediyne_Prodrugs/3680925
10.1021/jm015588e.s001