%0 Journal Article
%A Remiszewski, Stacy W.
%A Sambucetti, Lidia C.
%A Atadja, Peter
%A Bair, Kenneth W.
%A Cornell, Wendy D.
%A A. Green, Michael
%A Howell, Kobporn Lulu
%A Jung, Manfred
%A Kwon, Paul
%A Trogani, Nancy
%A Walker, Heather
%D 2002
%T Inhibitors of Human Histone
Deacetylase: Synthesis and Enzyme and
Cellular Activity of Straight Chain
Hydroxamates
%U https://acs.figshare.com/articles/journal_contribution/Inhibitors_of_Human_Histone_Deacetylase_Synthesis_and_Enzyme_and_Cellular_Activity_of_Straight_Chain_Hydroxamates/3680892
%R 10.1021/jm015568c.s001
%2 https://ndownloader.figshare.com/files/5770677
%K histone deacetylase
%K Straight Chain Hydroxamates Inhibitors
%K monolayer growth inhibition assays
%K p 21 waf 1
%K HDAC enzyme inhibition assay
%K tumor cell lines
%K terminal differentiation
%K SAHA
%K Cellular Activity
%K tumor cell lines differentially
%K suberoylanilide hydroxamic acid
%K antitumor effects
%X Inhibitors of histone deacetylase (HDAC) have been
shown to induce terminal differentiation of human tumor cell
lines and to have antitumor effects in vivo. We have prepared
analogues of suberoylanilide hydroxamic acid (SAHA) and
trichostatin A and have evaluated them in a human HDAC
enzyme inhibition assay, a p21waf1 (p21) promoter assay, and
in monolayer growth inhibition assays. One compound, 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide, was
found to affect the growth of a panel of eight human tumor
cell lines differentially.
%I ACS Publications