10.1371/journal.pgen.1002447.g009 Laia Navarro-Martín Laia Navarro-Martín Jordi Viñas Jordi Viñas Laia Ribas Laia Ribas Noelia Díaz Noelia Díaz Arantxa Gutiérrez Arantxa Gutiérrez Luciano Di Croce Luciano Di Croce Francesc Piferrer Francesc Piferrer Schematic diagram of the frequency distribution of the sb c<i>yp19a</i> promoter methylation levels in females and males. Public Library of Science 2011 diagram sb promoter methylation levels females 2011-12-29 02:12:16 Figure https://plos.figshare.com/articles/figure/_Schematic_diagram_of_the_frequency_distribution_of_the_sb_c_yp19a_promoter_methylation_levels_in_females_and_males_/367936 <p>Low methylation levels (purple curve) of the sb <i>cyp19a</i> promoter are typical of females and are required for ovarian differentiation. Males typically show high methylation levels (blue curve) of the <i>cyp19a</i> promoter. This blocks aromatase transcription and induces testicular differentiation caused by lack of estrogens. As shown in this study, high temperatures (HT) during the thermosensitive period increase methylation levels of the sb <i>cyp19a</i> promoter (red curve), shifting the female distribution closer to that of males. The dashed area represents the fraction of genotypic females that are sex reversed into phenotypic males by high temperature.</p>