Variations in the organization of nuclear content between normal (left), fibrocystic (middle) and metastatic (right) mammary epithelial cells (scale bar = 5 microns).
Vivek Nandakumar
Laimonas Kelbauskas
Kathryn F. Hernandez
Kelly M. Lintecum
Patti Senechal
Kimberly J. Bussey
Paul C. W. Davies
Roger H. Johnson
Deirdre R. Meldrum
10.1371/journal.pone.0029230.g005
https://plos.figshare.com/articles/figure/_Variations_in_the_organization_of_nuclear_content_between_normal_left_fibrocystic_middle_and_metastatic_right_mammary_epithelial_cells_scale_bar_8202_8202_5_microns_/367922
<p>Light gray haze depicts cytoplasm. Nuclear membrane is blue, low density regions of chromatin are green, moderate density regions are yellow, high density regions are orange, and nucleoli are magenta. Increased clumpiness is apparent in abnormal cells, and metastatic cell contains large number of smaller high-density clumps. Opacity of nuclear membrane (in blue) has been deliberately decreased to enable viewing of nuclear interior. Corresponding videos of these renderings are available in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029230#pone.0029230.s008" target="_blank">Movies S3</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029230#pone.0029230.s009" target="_blank">S4</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029230#pone.0029230.s010" target="_blank">S5</a>.</p>
2012-01-05 02:12:02
ANOVA
New Structural Alterations Background Grading schemes
fibrocystic
mushroom cap shape
breast cancer diagnosis
Abnormal cell nuclei
metastatic cell nuclei
metastatic cell populations
Malignant Breast Epithelial Cells
clumpier chromatin organization
Isotropic 3 D Nuclear Morphometry
3 D images
3 D
42 3 D
variation
2 D brightfield microscopy images