Enantioselective Indole Friedel−Crafts Alkylations Catalyzed by Bis(oxazolinyl)pyridine−Scandium(III) Triflate Complexes David A. Evans Karl A. Scheidt Keith R. Fandrick Hon Wai Lam Jimmy Wu 10.1021/ja036985c.s003 https://acs.figshare.com/articles/dataset/Enantioselective_Indole_Friedel_Crafts_Alkylations_Catalyzed_by_Bis_oxazolinyl_pyridine_Scandium_III_Triflate_Complexes/3654780 A highly enantioselective Friedel−Crafts alkylation of electron-rich aromatic nucleophiles catalyzed by scandium(III) triflate−pyridyl(bis)oxazoline complexes has been accomplished. The reaction involves α,β-unsaturated acyl phosphonates as electrophiles and primarily substituted indoles as nucleophiles. The reactive acyl phosphonate product is converted to the corresponding ester or amide in good overall yield by adding an alcohol or amine directly to the reaction mixture. 2003-08-13 00:00:00 Indole Enantioselective reaction mixture electrophile amine Alkylation indole enantioselective complex ester Triflate Bis alkylation Complexe Friedel scandium triflate Catalyzed nucleophile amide reactive acyl phosphonate product acyl phosphonates