Collot, Jérôme Gradinaru, Julieta Humbert, Nicolas Skander, Myriem Zocchi, Andrea Ward, Thomas R. Artificial Metalloenzymes for Enantioselective Catalysis Based on Biotin−Avidin Homogeneous and enzymatic catalysis offer complementary means to generate enantiomerically pure compounds. Incorporation of achiral biotinylated rhodium−diphosphine complexes into (strept)avidin yields artificial metalloenzymes for the hydrogenation of N-protected dehydroamino acids. A chemogenetic optimization procedure allows one to produce (<i>R</i>)-acetamidoalanine with 96% enantioselectivity. These hybrid catalysts display features reminiscent both of enzymatic and of homogeneous systems. enantioselectivity;catalysts display features;Homogeneou;metalloenzyme;acid;enantiomerically;acetamidoalanine;hydrogenation;complex;Incorporation;Biotin;biotinylated;catalysis offer;rhodium;Enantioselective Catalysis;achiral;compound;chemogenetic optimization procedure;dehydroamino;Artificial Metalloenzymes;yield;strept 2003-07-03
    https://acs.figshare.com/articles/journal_contribution/Artificial_Metalloenzymes_for_Enantioselective_Catalysis_Based_on_Biotin_Avidin/3651765
10.1021/ja035545i.s001