10.6084/m9.figshare.3635769.v1
Barbara Chudzik
Barbara
Chudzik
Arkadiusz Miaskowski
Arkadiusz
Miaskowski
Zbigniew Surowiec
Zbigniew
Surowiec
Grzegorz Czernel
Grzegorz
Czernel
Tomasz Duluk
Tomasz
Duluk
Andrzej Marczuk
Andrzej
Marczuk
Mariusz Gagoś
Mariusz
Gagoś
Effectiveness of magnetic fluid hyperthermia against <i>Candida albicans</i> cells
Taylor & Francis Group
2016
Candida albicans
electromagnetic field
magnetic fluid hyperthermia
magnetic nanoparticles
Mössbauer spectroscopy
2016-08-18 07:49:33
Journal contribution
https://tandf.figshare.com/articles/journal_contribution/Effectiveness_of_magnetic_fluid_hyperthermia_against_i_Candida_albicans_i_cells/3635769
<p><i>Candida albicans</i> is one of the most frequently isolated fungal pathogens causing opportunistic infections in humans. Targeted magnetic fluid hyperthermia (MFH) is a promising method in thermal therapy facilitating selective heating of pathogen cells like <i>C. albicans</i>. In the paper, we used <i>meso</i>-2,3-dimercaptosuccinic acid (DMSA)-coated magnetic nanoparticles (MNPs) and functionalised anti-<i>C. albicans</i> immunomagnetic nanoparticles (IMNPs) to investigate the potential of MFH in combating <i>C. albicans</i> cells <i>in vitro</i>. Using Mössbauer spectroscopy it was found that synthesised MNPs exhibited superparamagnetic phenomena. On the basis of calorimetric experiments, the maximum SAR (specific absorption rate) was found and a proper concentration of MNPs was established to control the temperature. MFH based on both DMSA-coated MNPs and functionalised anti-<i>C. albicans</i> IMNPs was more effective in combating <i>C. albicans</i> cells <i>in vitro</i> than thermostat hyperthermia. Especially promising results were obtained using functionalised IMNPs, which eradicated most of the pathogen colonies at the temperature of 43 °C.</p>