10.6084/m9.figshare.3635769.v1 Barbara Chudzik Barbara Chudzik Arkadiusz Miaskowski Arkadiusz Miaskowski Zbigniew Surowiec Zbigniew Surowiec Grzegorz Czernel Grzegorz Czernel Tomasz Duluk Tomasz Duluk Andrzej Marczuk Andrzej Marczuk Mariusz Gagoś Mariusz Gagoś Effectiveness of magnetic fluid hyperthermia against <i>Candida albicans</i> cells Taylor & Francis Group 2016 Candida albicans electromagnetic field magnetic fluid hyperthermia magnetic nanoparticles Mössbauer spectroscopy 2016-08-18 07:49:33 Journal contribution https://tandf.figshare.com/articles/journal_contribution/Effectiveness_of_magnetic_fluid_hyperthermia_against_i_Candida_albicans_i_cells/3635769 <p><i>Candida albicans</i> is one of the most frequently isolated fungal pathogens causing opportunistic infections in humans. Targeted magnetic fluid hyperthermia (MFH) is a promising method in thermal therapy facilitating selective heating of pathogen cells like <i>C. albicans</i>. In the paper, we used <i>meso</i>-2,3-dimercaptosuccinic acid (DMSA)-coated magnetic nanoparticles (MNPs) and functionalised anti-<i>C. albicans</i> immunomagnetic nanoparticles (IMNPs) to investigate the potential of MFH in combating <i>C. albicans</i> cells <i>in vitro</i>. Using Mössbauer spectroscopy it was found that synthesised MNPs exhibited superparamagnetic phenomena. On the basis of calorimetric experiments, the maximum SAR (specific absorption rate) was found and a proper concentration of MNPs was established to control the temperature. MFH based on both DMSA-coated MNPs and functionalised anti-<i>C. albicans</i> IMNPs was more effective in combating <i>C. albicans</i> cells <i>in vitro</i> than thermostat hyperthermia. Especially promising results were obtained using functionalised IMNPs, which eradicated most of the pathogen colonies at the temperature of 43 °C.</p>