Kohl, James V RNA-mediated physics, chemistry, and molecular epigenetics Olfaction and the innate immune system link energy as information from the epigenetic landscape to the physical landscape of supercoiled DNA. The sun's biological energy is the source of the information that links angstroms to ecosystems via physics, chemistry, and molecular epigenetics.<br>RNA-mediated protein folding chemistry and amino acid substitutions link the anti-entropic quantized energy of sunlight from the virucidal effects of ultraviolet (UV) light to healthy longevity via biophysically-constrained energy-dependent hydrogen-atom transfer in DNA base pairs in solution and cell type differentiation.<br>Biomarkers link energy-dependent differences in base pairs and amino acid substitutions to biosignatures across the healthy life span. RNA-mediated amino acid substitutions also reveal the increasing complexity of interactions among cell types as pathology progresses. For comparison, successful reproduction links energy from supercoiled DNA to protection of all organized genomes from virus-driven energy theft and pathology.<br>This model links the sun's biological energy from top-down causation in microbes to the most recent model of bottom-up gene activation and cell type differentiation in vertebrates. Citations to extant literature provide examples of what is currently known about how ecological variation leads to biophysically constrained cell type differentiation in the context of nutritional epigenetics and Precision Medicine, which clearly link metabolic networks and genetic networks to pharmacogenomics. ecosystem carbon dynamics;Epigenetic Gene Regulation;Amino acid sequence comparisons;Virus Adaptation Determines Virus Fitness;RNA bacteriophage;gene editing technology;longevity-selected;adaptation mechanisms;Cell type specific expression;isoform diversity;Animal Behaviour;Animal Cell and Molecular Biology;Animal Physiological Ecology;Animal Physiology - Biophysics;Behavioral Neuroscience;Behavioural Ecology;Biological Adaptation;Biophysics;Cell Biology;Cell Metabolism;Cellular Interactions (incl. Adhesion, Matrix, Cell Wall);Developmental Biology;Ecological Physiology;Epigenetics (incl. Genome Methylation and Epigenomics);Genetics;Infectious Diseases;Immunology;Life Histories;Medicine;Microbial Ecology;Molecular Biology;Neuroscience;Pathology;Proteomics and Intermolecular Interactions (excl. Medical Proteomics);Receptors and Membrane Biology;Signal Transduction;Speciation and Extinction;Structural Biology (incl. Macromolecular Modelling);Virology;Zoology 2016-08-01
    https://figshare.com/articles/dataset/RNA-mediated_physics_chemistry_and_molecular_epigenetics/3505913
10.6084/m9.figshare.3505913.v1