Nguyen, Hai Xuan Do, Truong Nhat Van Le, Tho Huu Thanh Thi Nguyen, Mai Nguyen, Nhan Trung Esumi, Hiroyasu Awale, Suresh Chemical Constituents of <i>Mangifera indica</i> and Their Antiausterity Activity against the PANC‑1 Human Pancreatic Cancer Cell Line Human pancreatic cancer cell lines such as PANC-1 have an altered metabolism, enabiling them to tolerate and survive under extreme conditions of nutrient starvation. The search for candidates that inhibit their viability during nutrition starvation represents a novel antiausterity strategy in anticancer drug discovery. A methanol extract of the bark of <i>Mangifera indica</i> was found to inhibit the survival of PANC-1 human pancreatic cancer cells preferentially under nutrient-deprived conditions with a PC<sub>50</sub> value of 15.5 μg/mL, without apparent toxicity, in normal nutrient-rich conditions. Chemical investigation on this bioactive extract led to the isolation of 19 compounds (<b>1</b>–<b>19</b>), including two new cycloartane-type triterpenes, mangiferolate A (<b>1</b>) and mangiferolate B (<b>2</b>). The structures of <b>1</b> and <b>2</b> were determined by NMR spectroscopic analysis. Among the isolated compounds, mangiferolate B (<b>2</b>) and isoambolic acid (<b>12</b>) exhibited potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under the nutrition-deprived condition with PC<sub>50</sub> values of 11.0 and 4.8 μM, respectively. Mangifera indica;pancreatic cancer cells;compound;PC 50 value;NMR spectroscopic analysis;starvation;Human;mangiferolate B;PC 50 values;4.8 μ M;novel antiausterity strategy;chemical;anticancer drug discovery;PANC 2016-07-28
    https://acs.figshare.com/articles/journal_contribution/Chemical_Constituents_of_i_Mangifera_indica_i_and_Their_Antiausterity_Activity_against_the_PANC_1_Human_Pancreatic_Cancer_Cell_Line/3504482
10.1021/acs.jnatprod.6b00381.s001