TY - DATA T1 - Chemical composition and antiparasitic activity of essential oils from leaves of Guatteria friesiana and Guatteria pogonopus (Annonaceae) PY - 2016/07/25 AU - Cássio S. Meira AU - Leociley R. A. Menezes AU - Tatiana B. dos Santos AU - Taís S. Macedo AU - José E. N. Fontes AU - Emmanoel V. Costa AU - Maria L. B. Pinheiro AU - Thanany B. da Silva AU - Elisalva Teixeira Guimarães AU - Milena B. P. Soares UR - https://tandf.figshare.com/articles/journal_contribution/Chemical_composition_and_antiparasitic_activity_of_essential_oils_from_leaves_of_i_Guatteria_friesiana_i_and_i_Guatteria_pogonopus_i_Annonaceae_/3497588 DO - 10.6084/m9.figshare.3497588.v1 L4 - https://ndownloader.figshare.com/files/5526866 KW - Guatteria friesiana KW - Guatteria pogonopus KW - essential oil KW - antimalarial activity KW - trypanocidal activity N2 - Natural products represent a valuable source for discovery of antiparasitic agents. Here, we describe the antiparasitic activity from essential oils extracted from leaves of Guatteria friesiana (EOGF) and Guatteria pogonopus (EOGP) (Annonaceae). The essential oils were obtained by hydrodistillation and analyzed by GC/MS and GC-FID. The sesquiterpenes are more abundant in both essential oils. G. friesiana are dominated by β-eudesmol (51.9%), γ-eudesmol (18.9%) andα-eudesmol (12.6%). The major compounds identified for EOGP were spathulenol (24.8%), γ-amorphene (14.7%) and germacrene D (11.8%). The essential oils demonstrated potent trypanocidal and antimalarial activities with values of IC50 lower than 41.3 μg/mL. EOGF also inhibits the proliferation of amastigotes. In addition, we identified significant ultrastructural alterations induced by the essential oils, especially in the cell membrane, Golgi complex, endoplasmatic reticulum and mitochondria. The results presented herein reinforce the potential of other members of this family for search of antiparasitic compounds. ER -