TY - DATA T1 - Supplementary Material for: Stratified Mucin-Producing Intraepithelial Lesion of the Cervix: Subtle Features Not to Be Missed PY - 2016/07/22 AU - Schwock J. AU - Ko H.M. AU - Dubé V. AU - Rouzbahman M. AU - Cesari M. AU - Ghorab Z. AU - Geddie W.R. UR - https://karger.figshare.com/articles/figure/Supplementary_Material_for_Stratified_Mucin-Producing_Intraepithelial_Lesion_of_the_Cervix_Subtle_Features_Not_to_Be_Missed/3494864 DO - 10.6084/m9.figshare.3494864.v1 L4 - https://ndownloader.figshare.com/files/5524400 L4 - https://ndownloader.figshare.com/files/5524403 L4 - https://ndownloader.figshare.com/files/5524406 L4 - https://ndownloader.figshare.com/files/5524409 KW - Stratified mucin-producing intraepithelial lesion KW - Cervix KW - Papanicolaou test KW - Human papillomavirus KW - Atypical glandular cells N2 - Objectives: Stratified mucin-producing intraepithelial lesion (SMILE) is an uncommon premalignant lesion of the uterine cervix. A detailed examination of preinvasive SMILE cases including a comparison of the cytologic features with usual-type adenocarcinoma in situ (AIS) and human papillomavirus (HPV) genotyping was performed. Study Design: Excisions and preceding Papanicolaou (Pap) tests were retrieved from the files of 2 tertiary care centers. Histologic review estimated the lesional SMILE proportion. Pap tests were reviewed and assessed for architectural, cellular and background features. Cobas® HPV test was performed. Results: 13 cases were identified. Mean/median patient age was 35/33 years (range 23-51 years). Concurrent high-grade squamous intraepithelial lesion was found in 10/13 (77%) and AIS in 8/13 (62%) cases. In 6 cases, SMILE was dominant (≥50%) and represented in 5/6 corresponding Pap tests. Cytology interpretations differed more often in the SMILE-dominant group (p < 0.05). SMILE and AIS had overlapping features. Feathering and prominent nucleoli were absent in SMILE. HPV DNA was detected in all 12 cases tested. HPV 18 was most common (7/12). Excisions with positive/suspicious margins were reported in 5/6 SMILE-dominant versus 3/7 nondominant cases. Conclusion:SMILE is best considered as an AIS variant for cytologic, etiologic and management purposes. Cytologic features overlap with AIS, but are more subtle and easily missed. HPV testing may play a role in facilitating SMILE detection. ER -