Ereshefsky, Benjamin J. Al-Hasan, Majdi N. Gokun, Yevgeniya Martin, Craig A. Comparison of ß-lactam plus aminoglycoside versus ß-lactam plus fluoroquinolone empirical therapy in serious nosocomial infections due to Gram-negative bacilli <p>We sought to compare clinical cure on day 7 and a 28-day all-cause mortality in patients who received an anti-pseudomonal ß-lactam with a fluoroquinolone or an aminoglycoside for treatment of nosocomial bacteremia or pneumonia due to Gram-negative bacilli while in the ICU. This retrospective cohort study was conducted in critically ill patients at an academic medical centre from January 2005 to August 2011. A total of 129 patients (83 receiving aminoglycoside and 46 receiving fluoroquinolone combinations) were included. Seven-day clinical cure rates were 74% and 72% for fluoroquinolone and aminoglycoside groups, respectively (<i>p</i> = 0.84). There was no significant difference in the odds of clinical cure with a fluoroquinolone as compared to an aminoglycoside combination (adjusted odds ratio 2.4, 95% confidence interval [CI] 0.7–9.0). There was no significant difference in 28-day mortality in patients who received a fluoroquinolone or an aminoglycoside combination (22% vs. 18%, adjusted hazard ratio 0.82, 95% CI 0.29–2.28).</p> Combination therapy;Nosocomial infection;Antibiotic therapy;Pneumonia;Bacteremia;Gram-negative bacilli 2016-07-04
    https://tandf.figshare.com/articles/journal_contribution/Comparison_of_-lactam_plus_aminoglycoside_versus_-lactam_plus_fluoroquinolone_empirical_therapy_in_serious_nosocomial_infections_due_to_Gram-negative_bacilli/3470516
10.6084/m9.figshare.3470516.v1