Gokcen, Taner Gulcin, Ilhami Ozturk, Turan Goren, Ahmet C. A class of sulfonamides as carbonic anhydrase I and II inhibitors <p>Four groups of novel sulfonamide derivatives: (i) acetoxybenzamide, (ii) triacetoxybenzamide, (iii) hydroxybenzamide and (iv) trihydroxybenzamide, all having thiazole, pyrimidine, pyridine, isoxazole and thiadiazole moieties were prepared and their inhibitory effects were studied on two metalloenzymes, i.e. carbonic anhydrase isozymes (hCA I and II), purified from human erythrocyte cells by Sepharose-4B-l-tyrosine-sulfanilamide affinity chromatography. These enzymes are present in almost all living organisms to catalyse the synthesis of bicarbonate ion (HCO<sub>3</sub><sup>−</sup>) from carbon dioxide and water. The sulfonamide derivatives were found to be active against hCA I and II in the range of 2.62–136.54 and 5.74–210.58 nM, respectively.</p> Enzyme inhibition;gallic acid;p-hydroxybenzoic acid 2016-06-29
    https://tandf.figshare.com/articles/journal_contribution/A_class_of_sulfonamides_as_carbonic_anhydrase_I_and_II_inhibitors/3466685
10.6084/m9.figshare.3466685.v1