10.6084/m9.figshare.3457535.v1 Koch A.K. Koch A.K. Klose P. Klose P. Lauche R. Lauche R. Cramer H. Cramer H. Baasch J. Baasch J. Dobos G.J. Dobos G.J. Langhorst J. Langhorst J. Supplementary Material for: A Systematic Review of Phytotherapy for Acute Rhinosinusitis Karger Publishers 2016 Rhinosinusitis Phytopharmaceuticals Phytotherapy Herbal medicine Review 2016-06-22 09:59:23 Dataset https://karger.figshare.com/articles/dataset/Supplementary_Material_for_A_Systematic_Review_of_Phytotherapy_for_Acute_Rhinosinusitis/3457535 <div>Herbal medicine is a promising alternative in the treatment</div><div>of acute rhinosinusitis (ARS). We performed a systematic</div><div>review for phytopharmaceutical treatments of</div><div>ARS. A computerized search of databases (Cochrane Library,</div><div>PubMed, and Scopus) up to 16 September 2015</div><div>was performed. Randomized controlled trials (RCTs) and</div><div>controlled trials (CTs) were included and assessed using</div><div>the Cochrane risk of bias tool. Seven trials on Pelargonium</div><div>sidoides (EPs 7630, Umckaloabo®), Myrtol (Gelo-</div><div>Myrtol® forte), BNO 1016 (Sinupret® extract), BNO 101</div><div>(Sinupret®), Cyclamen europaeum (Nasodren®), and Esberitox</div><div>® were included. Risk of bias was heterogeneous.</div><div>EPs 7630 appeared to be useful in the treatment of ARS.</div><div>Myrtol showed benefits against a placebo compound,</div><div>and BNO 1016 and BNO 101 might be helpful; however,</div><div>there was little evidence for the effectiveness of Cyclamen</div><div>europaeum and Esberitox®. Herbal medicine might</div><div>be effective for the treatment of ARS, but given the low</div><div>number of clinical trials and the heterogeneous methodological</div><div>quality, further research is necessary.</div>