Mazor, Yariv Yang, Chunning Borrok, M. Jack Ayriss, Joanne Aherne, Karen Wu, Herren F. Dall’Acqua, William Proposed model for how antibody binding affinity to target antigen regulates effector function potency. <p>Enhanced intrinsic affinity increases the likelihood for bivalent interaction with target cell. In contrast, a reduction in intrinsic affinity improves the probability for monovalent binding, leading to increased amount of antibody-Fc domains interacting with the target cell and hence better engagement with effector elements. However, additional reduction in intrinsic affinity, beyond a threshold of minimum affinity will result in poor cellular interaction and reduced effector functions.</p> effector function correlates;antibody binding valence;effector function potency;increase target cell opsonization;target antigen;Immune Effector Functions;antibody binding interactions;target cell lines;affinity antibodies;effector functions;role;saturating antibody concentrations 2016-06-20
    https://plos.figshare.com/articles/figure/Proposed_model_for_how_antibody_binding_affinity_to_target_antigen_regulates_effector_function_potency_/3455531
10.1371/journal.pone.0157788.g007