%0 Journal Article %A Katte, Timothy A. %A Reekie, Tristan A. %A Jorgensen, William T. %A Kassiou, Michael %D 2016 %T The Formation of Seven-Membered Heterocycles under Mild Pictet–Spengler Conditions: A Route to Pyrazolo[3,4]benzodiazepines %U https://acs.figshare.com/articles/journal_contribution/The_Formation_of_Seven_Membered_Heterocycles_under_Mild_Pictet_Spengler_Conditions_A_Route_to_Pyrazolo_3_4_benzodiazepines/3380227 %R 10.1021/acs.joc.6b00710.s001 %2 https://ndownloader.figshare.com/files/5226007 %K ketone %K Heterocycle %K Reported %K trifluoroacetic acid %K Formation %K aldehyde %K Pyrazolo %K method %K synthesis %K heterocycle %K Pictet %K acetic acid %K condensation %K Mild %K High substrate scope %X Reported is a method for the synthesis of seven-membered heterocycles via a Pictet–Spengler condensation reaction under very mild conditions. High substrate scope allows for use of aldehydes using catalytic amounts of acetic acid yielding 39–90% and ketones using catalytic amounts of trifluoroacetic acid yielding 25–83%. %I ACS Publications