%0 Journal Article %A Correa, Arkaitz %A Tellitu, Imanol %A Domínguez, Esther %A SanMartin, Raul %D 2006 %T Novel Alternative for the NN Bond Formation through a PIFA-Mediated Oxidative Cyclization and Its Application to the Synthesis of Indazol-3-ones %U https://acs.figshare.com/articles/journal_contribution/Novel_Alternative_for_the_N_i_i_N_Bond_Formation_through_a_PIFA_Mediated_Oxidative_Cyclization_and_Its_Application_to_the_Synthesis_of_Indazol_3_ones_sup_sup_/3372283 %R 10.1021/jo060070+.s001 %2 https://ndownloader.figshare.com/files/5215744 %K approach features %K series %K Cyclization %K Application %K intramolecular %K cyclization step %K methyl anthranilates %K access %K Formation %K Oxidative %K synthesis %K amine moiety %K heterocycle %K hypervalent iodine reagent PIFA %K formation %K acylnitrenium %K target N %K Bond %K disubstituted indazolone derivatives %K Indazol %K Synthesi %K bond %X The synthesis of a series of N,N-disubstituted indazolone derivatives starting from methyl anthranilates is presented. This general approach features a novel and easy way for access to the target N-heterocycles by formation of a new NN single bond. The key cyclization step embraces the formation of an N-acylnitrenium intermediate, mediated by the hypervalent iodine reagent PIFA, and its succeeding intramolecular trapping by the amine moiety under rather mild experimental conditions. %I ACS Publications