%0 Journal Article %A Dichtel, William R. %A Serin, Jason M. %A Edder, Carine %A M. J. Fréchet, Jean %A Matuszewski, Michael %A Tan, Loon-Seng %A Ohulchanskyy, Tymish Y. %A Prasad, Paras N. %D 2004 %T Singlet Oxygen Generation via Two-Photon Excited FRET %U https://acs.figshare.com/articles/journal_contribution/Singlet_Oxygen_Generation_via_Two_Photon_Excited_FRET/3340483 %R 10.1021/ja031647x.s001 %2 https://ndownloader.figshare.com/files/5179696 %K porphyrin model compound %K donor chromophores %K TPA %K Singlet Oxygen Generation %K FRET %K fluorescence %K excitation %K Enhanced singlet oxygen luminescence %X A new approach to two-photon excited photodynamic therapy has been developed. A dendritic array of eight donor chromophores capable of two-photon absorption (TPA) was covalently attached to a central porphyrin acceptor. Steady-state fluorescence measurements demonstrated that the donor chromophores transfer excited-state energy to the porphyrin with 97% efficiency. Two-photon excitation of the donor chromophores at 780 nm resulted in a dramatic increase in porphyrin fluorescence relative to a porphyrin model compound. Enhanced singlet oxygen luminescence was observed from oxygen-saturated solutions of the target compound under two-photon excitation conditions. %I ACS Publications