The Total Synthesis of (+)-Dragmacidin F Neil K. Garg Daniel D. Caspi Brian M. Stoltz 10.1021/ja046695b.s001 https://acs.figshare.com/articles/journal_contribution/The_Total_Synthesis_of_Dragmacidin_F/3328906 The first total synthesis of (+)-dragmacidin F has been accomplished, establishing the absolute configuration of this biologically important, antiviral marine alkaloid. The convergent route described features a palladium-mediated oxidative pyrrole carbocylization reaction to construct the [3.3.1] bicycle, as well as a highly selective Suzuki coupling to build the carbon skeleton of the natural product. A late-stage Neber rearrangement allows for the facile installation of the aminoimidazole moiety to provide (+)-dragmacidin F. 2004-08-11 00:00:00 convergent route dragmacidin pyrrole Neber carbocylization Suzuki marine alkaloid synthesis aminoimidazole moiety oxidative configuration installation Total Synthesis Dragmacidin carbon skeleton rearrangement