Liposomal Surface-Loading of
Water-Soluble Cationic Iron(III)
Porphyrins as Anticancer Drugs
Makoto Yuasa
Kenichi Oyaizu
Aiko Horiuchi
Akihiko Ogata
Tomomi Hatsugai
Aritomo Yamaguchi
Hiroyoshi Kawakami
10.1021/mp049936v.s001
https://acs.figshare.com/articles/journal_contribution/Liposomal_Surface_Loading_of_Water_Soluble_Cationic_Iron_III_Porphyrins_as_Anticancer_Drugs/3325441
A novel design of anticancer drug delivery
system, based on an electrostatic binding of negatively
charged liposomes and cationic metalloporphyrins under
physiological conditions, is reported. A lack of cytotoxicity
of the iron(III) porphyrin-loaded liposomes and an efficient
generation of a toxic hydroxyl radical (OH<sup>•</sup>) from a superoxide anion radical (O<sub>2</sub><sup>-•</sup>) through the iron(III)-catalyzed
dismutation and the Fenton-like reaction allow for a
targeted necrosis of tumor cells where the concentration
of O<sub>2</sub><sup>-•</sup> is locally increased as a result of the reduced
activity of superoxide dismutase and catalase in these
cells.Keywords: Anticancer drug delivery system; liposome; cationic metalloporphyrins; superoxide anion radical; hydroxyl
radical
2004-09-13 00:00:00
cationic metalloporphyrins
superoxide anion
Anticancer drug delivery system
anticancer drug delivery system
hydroxyl
OH
liposomes