Synthesis of a Gln-Phe
Hydroxy-ethylene Dipeptide Isostere
Bengt Erik Haug
Daniel H. Rich
10.1021/ol047879y.s001
https://acs.figshare.com/articles/journal_contribution/Synthesis_of_a_Gln_Phe_Hydroxy_ethylene_Dipeptide_Isostere/3312913
The protected Gln-Phe hydroxyethylene dipeptide isostere <b>1</b> was synthesized as a precursor for preparation of potential inhibitors of Botulinum
neurotoxin B metalloprotease. The method allows for the synthesis of additional hydroxyethylene dipeptide isosteres such as <b>2</b> with functionalized
P<sub>1</sub> side chains. The isosteres prepared were coupled with a dipeptide to produce protected pseudotetrapeptide derivatives.
2004-12-09 00:00:00
Botulinum neurotoxin B metalloprotease
functionalized P 1 side chains
hydroxyethylene dipeptide isosteres
pseudotetrapeptide derivatives