%0 Journal Article
%A W. B. van Leeuwen, Fijs
%A Verboom, Willem
%A Shi, Xiaodong
%A Davis, Jeffery T.
%A Reinhoudt, David N.
%D 2004
%T Selective 226Ra2+ Ionophores Provided by Self-Assembly of
Guanosine and Isoguanosine Derivatives
%U https://acs.figshare.com/articles/journal_contribution/Selective_sup_226_sup_Ra_sup_2_sup_Ionophores_Provided_by_Self_Assembly_of_Guanosine_and_Isoguanosine_Derivatives/3311212
%R 10.1021/ja0455650.s001
%2 https://ndownloader.figshare.com/files/5149945
%K Ra
%K 10 6
%K isoG 2 assembly
%X The self-assembled guanosine (G 1)-based hexadecamers and isoguanosine (isoG 2)-based
decamers are excellent 226Ra2+ selective ionophores even in the presence of excess alkali (Na+, K+, Rb+,
and Cs+) and alkaline earth (Mg2+, Ca2+, Sr2+, and Ba2+) cations over the pH range 3−11. G 1 requires
additional picrate anions to provide a neutral assembly, whereas the isoG 2 assembly extracts 226Ra2+
cations without any such additives. Both G 1−picrate and isoG 2 assemblies show 226Ra2+ extraction even
at a 0.35 × 106 fold excess of Na+, K+, Rb+, Cs+, Mg2+, or Ca2+ (10-2 M) to 226Ra2+ (2.9 × 10-8 M) and
at a 100-fold salt to ionophore excess. In the case of the G 1−picrate assembly, more competition was
observed from Sr2+ and Ba2+, as extraction of 226Ra2+ ceased at an M2+/226Ra2+ ratio of 106 and 104,
respectively. With the isoG 2 assembly, 226Ra2+ extraction also occurred at a Sr2+/226Ra2+ ratio of 106 but
ceased at a 106 excess of Ba2+. The results clearly demonstrate the power of molecular self-assembly for
the construction of highly selective ionophores.
%I ACS Publications