10.1021/ja044006q.s001 Jimena Fernández-Carneado Jimena Fernández-Carneado Michiel Van Gool Michiel Van Gool Vera Martos Vera Martos Susanna Castel Susanna Castel Pilar Prados Pilar Prados Javier de Mendoza Javier de Mendoza Ernest Giralt Ernest Giralt Highly Efficient, Nonpeptidic Oligoguanidinium Vectors that Selectively Internalize into Mitochondria American Chemical Society 2005 cancer cells drug delivery field confocal microscopy oligoarginine peptides flow cytometry nonpermeant drugs Nonpeptidic Oligoguanidinium Vectors anticancer drugs mitochondria tumor cells tetraguanidinium cell Selectively Internalize vector 2005-01-26 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Highly_Efficient_Nonpeptidic_Oligoguanidinium_Vectors_that_Selectively_Internalize_into_Mitochondria/3303244 Oligoguanidinium-based cell delivery systems have gained broad interest in the drug delivery field since one decade ago. Thus, arginine-containing peptides as Tat or Antp, oligoarginine peptides, and derived peptoids have been described as shuttles for delivering nonpermeant drugs inside cancer cells. Herein we report a new family of tetraguanidinium cell penetrating vectors efficiently internalized in human tumor cells. Their high internalization, studied by confocal microscopy and flow cytometry, as well as their specific accumulation in mitochondria makes these new vectors likely vehicles for the targeted delivery of anticancer drugs to mitochondria.