10.1021/ja044006q.s001
Jimena Fernández-Carneado
Jimena
Fernández-Carneado
Michiel Van Gool
Michiel Van
Gool
Vera Martos
Vera
Martos
Susanna Castel
Susanna
Castel
Pilar Prados
Pilar
Prados
Javier de Mendoza
Javier de
Mendoza
Ernest Giralt
Ernest
Giralt
Highly Efficient, Nonpeptidic Oligoguanidinium Vectors that
Selectively Internalize into Mitochondria
American Chemical Society
2005
cancer cells
drug delivery field
confocal microscopy
oligoarginine peptides
flow cytometry
nonpermeant drugs
Nonpeptidic Oligoguanidinium Vectors
anticancer drugs
mitochondria
tumor cells
tetraguanidinium cell
Selectively Internalize
vector
2005-01-26 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Highly_Efficient_Nonpeptidic_Oligoguanidinium_Vectors_that_Selectively_Internalize_into_Mitochondria/3303244
Oligoguanidinium-based cell delivery systems have gained broad interest in the drug delivery
field since one decade ago. Thus, arginine-containing peptides as Tat or Antp, oligoarginine peptides, and
derived peptoids have been described as shuttles for delivering nonpermeant drugs inside cancer cells.
Herein we report a new family of tetraguanidinium cell penetrating vectors efficiently internalized in human
tumor cells. Their high internalization, studied by confocal microscopy and flow cytometry, as well as their
specific accumulation in mitochondria makes these new vectors likely vehicles for the targeted delivery of
anticancer drugs to mitochondria.