Le Clézio, Ingrid Gornitzka, Heinz Escudier, Jean-Marc Vigroux, Alain Constrained Nucleic Acids (CNA). Part 2. Synthesis of Conformationally Restricted Dinucleotide Units Featuring Noncanonical α/β/γ or δ/ε/ζ Torsion Angle Combinations Four dinucleotide building units of nucleic acids in which three out of six backbone torsion angles are included in a dioxaphosphorinane ring structure (D-CNA family) have been synthesized:  two diastereoisomeric α,β,γ-D-CNA {cis and trans} and two diastereoisomeric δ,ε,ζ-D-CNA {(<i>S</i><sub>C4</sub><sub>‘</sub>,<i>R</i><sub>P</sub>) and (<i>S</i><sub>C4</sub><sub>‘</sub>,<i>S</i><sub>P</sub>)}. The structural analysis of these conformationally restricted dinucleotides, using NMR spectroscopy and X-ray crystallography, shows that these D-CNA structural elements allow the stabilization of torsion angle combinations, α/β/γ and δ/ε/ζ, that are significantly different from those typically observed in canonical A- or B-form duplexes. Restricted;Part 2. Synthesis;dinucleotide building units;Units;Featuring;acid;Combination;Constrained Nucleic Acids;backbone torsion angles;diastereoisomeric;crystallography;dioxaphosphorinane ring structure;canonical;stabilization;Noncanonical;CNA;NMR spectroscopy;Conformationally;conformationally;R P;duplexe;torsion angle combinations;tran;analysis;Dinucleotide;Torsion 2005-03-04
    https://acs.figshare.com/articles/dataset/Constrained_Nucleic_Acids_CNA_Part_2_Synthesis_of_Conformationally_Restricted_Dinucleotide_Units_Featuring_Noncanonical__or__Torsion_Angle_Combinations/3298258
10.1021/jo048136t.s001