10.1021/ja0500815.s002
Shengming Ma
Shengming
Ma
Zhenhua Gu
Zhenhua
Gu
PdCl<sub>2</sub>-Catalyzed Two-Component Cross-Coupling Cyclization of 2,3-Allenoic
Acids with 2,3-Allenols. An Efficient Synthesis of
4-(1‘,3‘-Dien-2‘-yl)-2(5<i>H</i>)-furanone Derivatives
American Chemical Society
2005
furanone
Allenoic
Cyclization
hydroxide
insertion
Derivative
allenol
acid
allenoic
oxypalladation
cyclization
Efficient Synthesis
Dien
allene
derivative
PdCl 2
dien
stereoselectivity
elimination
Catalyzed
Allenol
Acid
bond
2005-05-04 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/PdCl_sub_2_sub_Catalyzed_Two_Component_Cross_Coupling_Cyclization_of_2_3_Allenoic_Acids_with_2_3_Allenols_An_Efficient_Synthesis_of_4_1_3_Dien_2_yl_2_5_i_H_i_furanone_Derivatives/3288076
Cross-coupling cyclization reaction between 2,3-allenoic acids <b>1</b> and 2,3-allenols <b>2</b>, in which two allenes functioned differently, was realized to afford 4-(1‘,3‘-dien-2‘-yl)-2(5<i>H</i>)-furanone derivatives <b>3</b>. The reaction may proceed via an oxypalladation, insertion, and β-hydroxide elimination process. A high <i>E</i>-stereoselectivity of the new formed CC double bond was observed.