10.1021/ja0500815.s002 Shengming Ma Shengming Ma Zhenhua Gu Zhenhua Gu PdCl<sub>2</sub>-Catalyzed Two-Component Cross-Coupling Cyclization of 2,3-Allenoic Acids with 2,3-Allenols. An Efficient Synthesis of 4-(1‘,3‘-Dien-2‘-yl)-2(5<i>H</i>)-furanone Derivatives American Chemical Society 2005 furanone Allenoic Cyclization hydroxide insertion Derivative allenol acid allenoic oxypalladation cyclization Efficient Synthesis Dien allene derivative PdCl 2 dien stereoselectivity elimination Catalyzed Allenol Acid bond 2005-05-04 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/PdCl_sub_2_sub_Catalyzed_Two_Component_Cross_Coupling_Cyclization_of_2_3_Allenoic_Acids_with_2_3_Allenols_An_Efficient_Synthesis_of_4_1_3_Dien_2_yl_2_5_i_H_i_furanone_Derivatives/3288076 Cross-coupling cyclization reaction between 2,3-allenoic acids <b>1</b> and 2,3-allenols <b>2</b>, in which two allenes functioned differently, was realized to afford 4-(1‘,3‘-dien-2‘-yl)-2(5<i>H</i>)-furanone derivatives <b>3</b>. The reaction may proceed via an oxypalladation, insertion, and β-hydroxide elimination process. A high <i>E</i>-stereoselectivity of the new formed CC double bond was observed.