Stereoselective Synthesis of the
Tetrahydropyran Core of
Polycarvernoside A
Conor S. Barry
Nick Bushby
John R. Harding
Christine L. Willis
10.1021/ol050840o.s001
https://acs.figshare.com/articles/journal_contribution/Stereoselective_Synthesis_of_the_Tetrahydropyran_Core_of_Polycarvernoside_A/3280978
A concise and stereoselective synthesis of the tetrasubstituted tetrahydropyran core of polycavernoside A was achieved in 55% overall yield
from 3-benzyloxypropanal. A stereoselective allyl transfer reaction was used in the synthesis of enol ether <b>18</b> followed by a TFA-mediated
cyclization to create the three new asymmetric centers in the tetrahydropyran with complete stereocontrol in a single-pot process.
2005-06-23 00:00:00
Tetrahydropyran Core
Polycarvernoside
Stereoselective Synthesis
cyclization
enol ether 18
stereocontrol
polycavernoside
stereoselective allyl transfer reaction
stereoselective synthesis
center
tetrasubstituted tetrahydropyran core
benzyloxypropanal