Stereoselective Synthesis of the Tetrahydropyran Core of Polycarvernoside A Conor S. Barry Nick Bushby John R. Harding Christine L. Willis 10.1021/ol050840o.s001 https://acs.figshare.com/articles/journal_contribution/Stereoselective_Synthesis_of_the_Tetrahydropyran_Core_of_Polycarvernoside_A/3280978 A concise and stereoselective synthesis of the tetrasubstituted tetrahydropyran core of polycavernoside A was achieved in 55% overall yield from 3-benzyloxypropanal. A stereoselective allyl transfer reaction was used in the synthesis of enol ether <b>18</b> followed by a TFA-mediated cyclization to create the three new asymmetric centers in the tetrahydropyran with complete stereocontrol in a single-pot process. 2005-06-23 00:00:00 Tetrahydropyran Core Polycarvernoside Stereoselective Synthesis cyclization enol ether 18 stereocontrol polycavernoside stereoselective allyl transfer reaction stereoselective synthesis center tetrasubstituted tetrahydropyran core benzyloxypropanal