10.1021/ol050840o.s001 Conor S. Barry Conor S. Barry Nick Bushby Nick Bushby John R. Harding John R. Harding Christine L. Willis Christine L. Willis Stereoselective Synthesis of the Tetrahydropyran Core of Polycarvernoside A American Chemical Society 2005 Tetrahydropyran Core Polycarvernoside Stereoselective Synthesis cyclization enol ether 18 stereocontrol polycavernoside stereoselective allyl transfer reaction stereoselective synthesis center tetrasubstituted tetrahydropyran core benzyloxypropanal 2005-06-23 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Stereoselective_Synthesis_of_the_Tetrahydropyran_Core_of_Polycarvernoside_A/3280978 A concise and stereoselective synthesis of the tetrasubstituted tetrahydropyran core of polycavernoside A was achieved in 55% overall yield from 3-benzyloxypropanal. A stereoselective allyl transfer reaction was used in the synthesis of enol ether <b>18</b> followed by a TFA-mediated cyclization to create the three new asymmetric centers in the tetrahydropyran with complete stereocontrol in a single-pot process.