Practical Synthesis of Unsymmetrical
Ureas from Isopropenyl Carbamates
Isabelle Gallou
Magnus Eriksson
Xingzhong Zeng
Chris Senanayake
Vittorio Farina
10.1021/jo0507643.s001
https://acs.figshare.com/articles/journal_contribution/Practical_Synthesis_of_Unsymmetrical_Ureas_from_Isopropenyl_Carbamates/3271996
A very convenient method for the synthesis of unsymmetrical ureas is described, based on isopropenyl carbamates. The synthetic efficiency of traditional methods for urea
formation, such as use of phosgene or alkyl and aryl
carbamates, is limited by the formation of symmetrical urea
side products or reaction reversibility. Isopropenyl carbamates react with amines cleanly and irreversibly and give
unsymmetrical ureas in high yield and purity. This method
is ideal for the rapid synthesis of compound libraries.
2005-08-19 00:00:00
urea side products
carbamate
method
synthesis
formation
Isopropenyl
unsymmetrical ureas