%0 Journal Article %A Hummel, Conrad W. %A Geiser, Andrew G. %A Bryant, Henry U. %A Cohen, Ilene R. %A D. Dally, Robert %A Fong, Kin Chiu %A Frank, Scott A. %A Hinklin, Ronald %A Jones, Scott A. %A Lewis, George %A McCann, Denis J. %A Rudmann, Daniel G. %A Shepherd, Timothy A. %A Tian, Hongqi %A Wallace, Owen B. %A Wang, Minmin %A Wang, Yong %A Dodge, Jeffrey A. %D 2005 %T A Selective Estrogen Receptor Modulator Designed for the Treatment of Uterine Leiomyoma with Unique Tissue Specificity for Uterus and Ovaries in Rats %U https://acs.figshare.com/articles/journal_contribution/A_Selective_Estrogen_Receptor_Modulator_Designed_for_the_Treatment_of_Uterine_Leiomyoma_with_Unique_Tissue_Specificity_for_Uterus_and_Ovaries_in_Rats/3259084 %R 10.1021/jm050723z.s001 %2 https://ndownloader.figshare.com/files/5094490 %K uterine leiomyoma %K ER α %K SERM %K uterine antagonist %K estrogen receptor modulator %K affinity %K histologic evaluation %K Uteru %K Uterine Leiomyoma %K Ovarie %K estrogen receptors α %K serum biomarkers %K Unique Tissue Specificity %K Rats %K Selective Estrogen Receptor Modulator %K ovarie %K LY %X The design of a novel selective estrogen receptor modulator (SERM) for the potential treatment of uterine leiomyoma is described. 16 (LY2066948−HCl) binds with high affinity to estrogen receptors α and β (ERα and ERβ, respectively) and is a potent uterine antagonist with minimal effects on the ovaries as determined by serum biomarkers and histologic evaluation. %I ACS Publications