A Selective Estrogen Receptor Modulator
Designed for the Treatment of Uterine
Leiomyoma with Unique Tissue
Specificity for Uterus and Ovaries in
Rats
Conrad W. Hummel
Andrew G. Geiser
Henry U. Bryant
Ilene R. Cohen
Robert D. Dally
Kin Chiu Fong
Scott A. Frank
Ronald Hinklin
Scott A. Jones
George Lewis
Denis J. McCann
Daniel G. Rudmann
Timothy A. Shepherd
Hongqi Tian
Owen B. Wallace
Minmin Wang
Yong Wang
Jeffrey A. Dodge
10.1021/jm050723z.s001
https://acs.figshare.com/articles/journal_contribution/A_Selective_Estrogen_Receptor_Modulator_Designed_for_the_Treatment_of_Uterine_Leiomyoma_with_Unique_Tissue_Specificity_for_Uterus_and_Ovaries_in_Rats/3259084
The design of a novel selective estrogen receptor
modulator (SERM) for the potential treatment of uterine
leiomyoma is described. <b>16</b> (LY2066948−HCl) binds with high
affinity to estrogen receptors α and β (ERα and ERβ, respectively) and is a potent uterine antagonist with minimal effects
on the ovaries as determined by serum biomarkers and
histologic evaluation.
2005-11-03 00:00:00
uterine leiomyoma
ER α
SERM
uterine antagonist
estrogen receptor modulator
affinity
histologic evaluation
Uteru
Uterine Leiomyoma
Ovarie
estrogen receptors α
serum biomarkers
Unique Tissue Specificity
Rats
Selective Estrogen Receptor Modulator
ovarie
LY