A Selective Estrogen Receptor Modulator Designed for the Treatment of Uterine Leiomyoma with Unique Tissue Specificity for Uterus and Ovaries in Rats Conrad W. Hummel Andrew G. Geiser Henry U. Bryant Ilene R. Cohen Robert D. Dally Kin Chiu Fong Scott A. Frank Ronald Hinklin Scott A. Jones George Lewis Denis J. McCann Daniel G. Rudmann Timothy A. Shepherd Hongqi Tian Owen B. Wallace Minmin Wang Yong Wang Jeffrey A. Dodge 10.1021/jm050723z.s001 https://acs.figshare.com/articles/journal_contribution/A_Selective_Estrogen_Receptor_Modulator_Designed_for_the_Treatment_of_Uterine_Leiomyoma_with_Unique_Tissue_Specificity_for_Uterus_and_Ovaries_in_Rats/3259084 The design of a novel selective estrogen receptor modulator (SERM) for the potential treatment of uterine leiomyoma is described. <b>16</b> (LY2066948−HCl) binds with high affinity to estrogen receptors α and β (ERα and ERβ, respectively) and is a potent uterine antagonist with minimal effects on the ovaries as determined by serum biomarkers and histologic evaluation. 2005-11-03 00:00:00 uterine leiomyoma ER α SERM uterine antagonist estrogen receptor modulator affinity histologic evaluation Uteru Uterine Leiomyoma Ovarie estrogen receptors α serum biomarkers Unique Tissue Specificity Rats Selective Estrogen Receptor Modulator ovarie LY