10.1021/jm0507173.s001
Hye-Young Kim
Hye-Young
Kim
Derek A. Pratt
Derek A.
Pratt
Jennifer R. Seal
Jennifer R.
Seal
Maikel Wijtmans
Maikel
Wijtmans
Ned A. Porter
Ned A.
Porter
Lipid-Soluble 3-Pyridinol Antioxidants
Spare α-Tocopherol and Do Not
Efficiently Mediate Peroxidation of
Cholesterol Esters in Human
Low-Density Lipoprotein
American Chemical Society
2005
Efficiently Mediate Peroxidation
Cholesterol Esters
TOH
Tocopherol
lipid peroxidation
LDL
onset
mediate
Lipoprotein
tocopherol
Pyridinol
Herein
lipoprotein tryptophan residues
Antioxidant
pyridinol
atherosclerosi
Human
prevention
2005-11-03 00:00:00
Journal contribution
https://acs.figshare.com/articles/journal_contribution/Lipid_Soluble_3_Pyridinol_Antioxidants_Spare_Tocopherol_and_Do_Not_Efficiently_Mediate_Peroxidation_of_Cholesterol_Esters_in_Human_Low_Density_Lipoprotein/3259081
Because α-tocopherol (α-TOH) mediates the peroxidation of cholesterol-esterified lipids in human low-density
lipoprotein (LDL) in vitro and has displayed disappointing
results against the onset and development of atherosclerosis,
it may not be appropriate for use as a therapeutic in the
prevention and/or treatment of the disease. Herein are described the experimental results demonstrating that 3-pyridinols spare α-TOH, do not efficiently mediate lipid peroxidation, and protect lipoprotein tryptophan residues in human
LDL.