10.1021/jm0507173.s001 Hye-Young Kim Hye-Young Kim Derek A. Pratt Derek A. Pratt Jennifer R. Seal Jennifer R. Seal Maikel Wijtmans Maikel Wijtmans Ned A. Porter Ned A. Porter Lipid-Soluble 3-Pyridinol Antioxidants Spare α-Tocopherol and Do Not Efficiently Mediate Peroxidation of Cholesterol Esters in Human Low-Density Lipoprotein American Chemical Society 2005 Efficiently Mediate Peroxidation Cholesterol Esters TOH Tocopherol lipid peroxidation LDL onset mediate Lipoprotein tocopherol Pyridinol Herein lipoprotein tryptophan residues Antioxidant pyridinol atherosclerosi Human prevention 2005-11-03 00:00:00 Journal contribution https://acs.figshare.com/articles/journal_contribution/Lipid_Soluble_3_Pyridinol_Antioxidants_Spare_Tocopherol_and_Do_Not_Efficiently_Mediate_Peroxidation_of_Cholesterol_Esters_in_Human_Low_Density_Lipoprotein/3259081 Because α-tocopherol (α-TOH) mediates the peroxidation of cholesterol-esterified lipids in human low-density lipoprotein (LDL) in vitro and has displayed disappointing results against the onset and development of atherosclerosis, it may not be appropriate for use as a therapeutic in the prevention and/or treatment of the disease. Herein are described the experimental results demonstrating that 3-pyridinols spare α-TOH, do not efficiently mediate lipid peroxidation, and protect lipoprotein tryptophan residues in human LDL.