TY - DATA T1 - Single-Step Syntheses of 2-Amino-7-chlorothiazolo[5,4-d]pyrimidines:  Intermediates for Bivalent Thiazolopyrimidines PY - 2005/11/25 AU - Jian Liu AU - Raymond J. Patch AU - Carsten Schubert AU - Mark R. Player UR - https://acs.figshare.com/articles/dataset/Single_Step_Syntheses_of_2_Amino_7_chlorothiazolo_5_4_i_d_i_pyrimidines_Intermediates_for_Bivalent_Thiazolopyrimidines/3255253 DO - 10.1021/jo0517702.s001 L4 - https://ndownloader.figshare.com/files/5090629 KW - arylamine nucleophiles KW - Bivalent Thiazolopyrimidines KW - functionalized isothiocyanates N2 - A single-step process for the preparation of 2-amino-7-chlorothiazolo[5,4-d]pyrimidines, 2, was achieved by the reaction of the commercially available 4,6-dichloro-5-aminopyrimidine 1 with isothiocyanates. This mild reaction accommodates a variety of functionalized isothiocyanates and proceeds in good to excellent yields. The utility of such intermediates is exemplified by subsequent reaction with alkyl or arylamine nucleophiles to afford novel, differentially functionalized 2,7-diaminothiazolo[5,4-d]pyrimidines, 3. ER -