10.1021/jo0517702.s001
Jian Liu
Jian
Liu
Raymond J. Patch
Raymond J.
Patch
Carsten Schubert
Carsten
Schubert
Mark R. Player
Mark R.
Player
Single-Step Syntheses of
2-Amino-7-chlorothiazolo[5,4-<i>d</i>]pyrimidines:
Intermediates for Bivalent
Thiazolopyrimidines
American Chemical Society
2005
arylamine nucleophiles
Bivalent Thiazolopyrimidines
functionalized isothiocyanates
2005-11-25 00:00:00
Dataset
https://acs.figshare.com/articles/dataset/Single_Step_Syntheses_of_2_Amino_7_chlorothiazolo_5_4_i_d_i_pyrimidines_Intermediates_for_Bivalent_Thiazolopyrimidines/3255253
A single-step process for the preparation of 2-amino-7-chlorothiazolo[5,4-<i>d</i>]pyrimidines, <b>2</b>, was achieved by the
reaction of the commercially available 4,6-dichloro-5-aminopyrimidine <b>1</b> with isothiocyanates. This mild reaction
accommodates a variety of functionalized isothiocyanates
and proceeds in good to excellent yields. The utility of such
intermediates is exemplified by subsequent reaction with
alkyl or arylamine nucleophiles to afford novel, differentially
functionalized 2,7-diaminothiazolo[5,4-<i>d</i>]pyrimidines, <b>3</b>.